Phosphorylated MLKL causes plasma membrane rupture
نویسندگان
چکیده
منابع مشابه
Phosphorylated MLKL causes plasma membrane rupture
paper type paper type COMMeNtary Necroptosis, cell death caused by uncontrolled swelling (oncosis) and rapid plasma membrane rupture, exerts detrimental pathogenic effects. According to recent reports by Wang et al. 3 in Molecular Cell and Dondelinger et al. 4 in Cell Reports, the underlying mechanism of necroptosis might involve the assembly of pore-forming oligomers of phosphory-lated mixed l...
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Although mixed lineage kinase domain-like (MLKL) protein has emerged as a specific and crucial protein for necroptosis induction, how MLKL transduces the death signal remains poorly understood. Here, we demonstrate that the full four-helical bundle domain (4HBD) in the N-terminal region of MLKL is required and sufficient to induce its oligomerization and trigger cell death. Moreover, we found t...
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When a plasma membrane-enriched fraction isolated from red beet (Beta vulgaris L.) was incubated in the presence of 40 micromolar [gamma-(32)P] ATP, 40 micromolar MgSO(4) at pH 6.5, a rapidly turning over phosphorylated protein was formed. Phosphorylation of the protein was substrate-specific for ATP, sensitive to diethylstilbestrol and vanadate, but insensitive to azide. When the dephosphoryla...
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ژورنال
عنوان ژورنال: Molecular & Cellular Oncology
سال: 2014
ISSN: 2372-3556
DOI: 10.4161/mco.29915